光动力疗法(Photodynamic Therapy, PDT)是结合光和光敏药物治疗肿瘤和皮肤性病的新方法,具有创伤小、选择性好、适用范围广、非侵入性等特点。
•激发波长处于最佳“生物光学窗口”(700-850 nm), 组织穿透深度可达到10 mm左右,高反应活性
•原创生物正交技术,有效提高药物靶向性,为精准治疗提供可能性
•原位检测治疗过程: 影像介入光动力治疗
本项目开发系列具有高光敏活性、宽近红外窗口、高穿透深度的光敏剂原型药物,解决光敏剂在光动力治疗临床应用中的光敏活性、穿透深度、靶向性等关键技术难点。
Photodynamic Therapy (PDT) is a new treatment of tumor and skin diseases by combining light and photosensitizing drugs,which features small trauma (even non-invasiveness), good selectivity and wide application range.
•Excitation wavelength at "bio-optical window" (700-850 nm), the tissue penetration depth up to 10 mm, and high PDT reactivity
•Original bio-orthogonal technology: improve drug targeting and potential for precise treatment
•In situ monitoring the treatment process combing imaging and PDT
We aim to develop a series of prototypes of photosensitizers with high photosensitivity, wide near-infrared window and high penetration depth, which are perspective to overcome the key issues of photosensitizers occurring in clinical PDT applications.